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The right ventricle exhibits significantly lower sarcoplasmic reticulum calcium uptake rates and prolonged calcium transients compared to the left ventricle, primarily due to a higher proportion of phospholamban-bound, functionally inert Ca2+-ATPase molecules. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 4, 2006AJP Heart and Circulatory Physiology

Mechanistic basis of differences in Ca2+-handling properties of sarcoplasmic reticulum in right and left ventricles of normal rat myocardium

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Authors

VSVenkatachalem SathishDakota State University AXAlex XuUniversity Hospitals of Cleveland MKMorris KarmazynWestern University

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Implication

May inform ventricle-specific HF strategies; leaves open translation from rat models to patients.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Sathish et al. (2006) studied this question.

synapsesocial.com/papers/6a051118fba2ba61ab55fa7e https://doi.org/10.1152/ajpheart.01372.2005

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Mechanistic basis of differences in Ca2+-handling properties of sarcoplasmic reticulum in right and left ventricles of normal rat myocardium

Discussion

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Implication

Key Points

Cite This Study

Mechanistic basis of differences in Ca2+-handling properties of sarcoplasmic reticulum in right and left ventricles of normal rat myocardium

Discussion

Member takes

Implication

Key Points

Cite This Study

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