Key result
Cigarette smoking in women was associated with significantly higher urinary excretion of thromboxane A2 and prostacyclin metabolites compared to nonsmokers (p < 0.001).
Why the study?
Does cigarette smoking increase urinary excretion of thromboxane A2 and prostacyclin metabolites in healthy women?
Population
250 healthy women, aged 18-59 years, working in a Swedish hospital. Excluded: symptoms or clinical signs of…
Comparison
Current cigarette smoking vs Nonsmoking
Design
Cross-sectional
Authors
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May signal elevated thrombotic potential in female smokers; extends cross-sectional evidence but requires longitudinal validation.
Observational (n=250)
Does cigarette smoking increase urinary excretion of thromboxane A2 and prostacyclin metabolites in healthy women?
p-value: p=<0.001
Cigarette smoking in women is associated with increased platelet activity and platelet/vessel wall interaction, which is dependent on smoking intensity and reversible upon quitting.
Rångemark et al. (1992) conducted an observational in Healthy female smokers and nonsmokers (n=250). Cigarette smoking vs. Nonsmoking was evaluated on Urinary excretion of 2,3-dinormetabolites of thromboxane A2 (Tx-M) and prostacyclin (PGI-M) (p=<0.001). Cigarette smoking in women was associated with significantly higher urinary excretion of thromboxane A2 and prostacyclin metabolites compared to nonsmokers (p < 0.001).
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