Why the study?
Does cigarette smoking alter the balance of proaggregatory thromboxane A2 and antiaggregatory nitric oxide/prostacyclin in healthy females?
Population
49 healthy females, comprising 23 smokers and 26 matched non-smokers.
Comparison
Cigarette smoking (11-20 cigarettes per day) vs Matched non-smokers
Design
Cross-sectional
Authors
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Suggests unopposed TxA2 elevation may heighten thrombotic risk in female smokers; hypothesis-generating for smoking-related CVD mechanisms.
Does cigarette smoking alter the balance of proaggregatory thromboxane A2 and antiaggregatory nitric oxide/prostacyclin in healthy females?
In healthy female smokers, increased proaggregatory thromboxane A2 formation is not counterbalanced by inhaled nitric oxide or enhanced prostacyclin formation, potentially contributing to increased cardiovascular risk.
Åström et al. (1996) studied this question.
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