Key result
Cigarette smoking, both acute and chronic, did not affect whole blood platelet aggregation, whereas aggregation was significantly greater in females than males (P<0.001 for ADP and collagen).
Why the study?
Does cigarette smoking or sex affect whole blood platelet aggregation in normal subjects?
Cross-Sectional (n=23)
Does cigarette smoking or sex affect whole blood platelet aggregation in normal subjects?
Cigarette smoking does not appear to directly affect whole blood platelet aggregability, but females exhibit significantly higher baseline platelet aggregation than males.
Answers are grounded in this paper and cite their sources.
Smoking need not confound platelet aggregation interpretation; leaves open whether sex differences affect thrombotic risk or therapy response.
In normal subjects, 18-49 years old, the effects of the smoking habit (greater than 10 cigarettes/day) and the act of smoking two cigarettes over 10 min were studied on whole blood platelet aggregation (in vitro impedance method). 2. Acute smoking (n = 10) did not affect platelet aggregation to ADP, collagen or to platelet activating factor (PAF) nor thromboxane B2 production during aggregation. There was no difference between smokers (n = 13) and non-smokers (n = 10). However, aggregation to all aggregants was greater in females (n = 11) than males (n = 12) (ADP and collagen, P less than 0.001; PAF, P less than 0.01; ANOVA). 3. Although others have obtained diverse results studying platelet-rich plasma, the absence of an effect of cigarette smoking on whole blood platelet aggregation is consistent with many of those observations. Greater in vitro aggregability in females than males is consistent with the few studies of platelet-rich plasma. It seems unlikely that the role of cigarette smoking as a risk factor for ischaemic heart disease is related to a direct effect on platelet aggregability.
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Taylor et al. (1987) conducted a cross-sectional in Healthy subjects (n=23). Cigarette smoking vs. Non-smokers was evaluated on Whole blood platelet aggregation to ADP, collagen, or PAF. Cigarette smoking, both acute and chronic, did not affect whole blood platelet aggregation, whereas aggregation was significantly greater in females than males (P<0.001 for ADP and collagen).
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