Key result
Smoking 2 cigarettes immediately increased ADP-induced platelet aggregation and adhesiveness in young heavy smokers, but not in older subjects with or without cerebrovascular disease.
Why the study?
Does smoking 2 cigarettes immediately increase ADP-induced platelet aggregation and adhesiveness in heavy smokers?
Observational (n=32)
Does smoking 2 cigarettes immediately increase ADP-induced platelet aggregation and adhesiveness in heavy smokers?
Smoking acutely increases platelet aggregation and adhesiveness in young heavy smokers, suggesting a mechanism for increased thrombotic risk in this demographic.
Answers are grounded in this paper and cite their sources.
Acute smoking may heighten thrombotic risk via platelet effects in young heavy smokers; leaves open generalizability to older patients.
The immediate effect of cigarette-smoking on ADP-induced platelet aggregation and on platelet adhesiveness was investigated in 12 normal subjects aged 20 to 40, in 10 normal subjects aged 43 to 72 and in 10 patients with cerebrovascular disease aged 45 to 75. All the subjects were heavy smokers (more than 20 cigarettes a day). After smoking 2 cigarettes a significant increase in ADP aggregation and platelet adhesiveness was found in the group of young heavy smokers, while in the old subjects with or without cerebrovascular disease the increase in platelet activity was never significant. These data were discussed and some hypotheses for this higher reactivity of platelets from young people were suggested.
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Grignani et al. (1977) conducted an observational in Healthy subjects and cerebrovascular disease (n=32). Smoking 2 cigarettes vs. Baseline (pre-smoking) was evaluated on ADP-induced platelet aggregation and platelet adhesiveness. Smoking 2 cigarettes immediately increased ADP-induced platelet aggregation and adhesiveness in young heavy smokers, but not in older subjects with or without cerebrovascular disease.
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