Key result
Smoking two cigarettes after a 12-hour abstinence significantly increased mean collagen-induced platelet aggregation from 45 to 68 chart units immediately after smoking (P<0.005).
Why the study?
Does cigarette smoking increase platelet aggregability in male habitual smokers?
Does cigarette smoking increase platelet aggregability in male habitual smokers?
A 20-minute period of cigarette smoking after overnight abstinence significantly enhances platelet aggregability for up to 2 hours in habitual smokers.
May warrant pre-procedural smoking abstinence in habitual smokers; leaves open whether this platelet effect drives acute cardiovascular events.
Eight male habitual smokers smoked two cigarettes over a 20-min period following a 12-h period of abstinence. Antecubital venipuncture was performed immediately before, immediately after, and 55 min and 2 h after smoking had ceased. At these times, the mean values (+/- SD) of collagen-induced platelet aggregation were 45 +/- 5, 68 +/- 5, 59 +/- 6 and 52 +/- 5 chart units, respectively, while the corresponding values for the mean platelet aggregate ratio were 0.91 +/- 0.01, 0.82 +/- 0.03, 0.87 +/- 0.02 and 0.90 +/- 0.02, respectively. Mean collagen-induced platelet aggregation was significantly (P less than 0.005) higher immediately after, and 55 min and 2 h after smoking. The mean platelet aggregate ratio was significantly (P less than 0.001) lower immediately after and 55 min after smoking. Correlation coefficients between the concentration of nicotine in each of the 24 plasma samples obtained after smoking and the corresponding values of collagen-induced platelet aggregation and the platelet aggregate ratio were 0.41 (P less than 0.05) and -0.50 (P less than 0.02), respectively. It is concluded that when habitual smokers abstain from smoking overnight, a 20-min period of cigarette smoking may enhance platelet aggregability for as long as 2 h.
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Davis et al. (1992) studied Habitual smokers (n=8). Cigarette smoking vs. Baseline (12-hour abstinence) was evaluated on Collagen-induced platelet aggregation (p=<0.005). Smoking two cigarettes after a 12-hour abstinence significantly increased mean collagen-induced platelet aggregation from 45 to 68 chart units immediately after smoking (P<0.005).
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