Why the study?
Does cigarette smoking induce acute in vivo platelet activation in healthy subjects?
Does cigarette smoking induce acute in vivo platelet activation in healthy subjects?
Cigarette smoking induces rapid acute in vivo platelet activation within 10 to 30 minutes in healthy subjects.
Acute smoking-linked platelet activation may elevate thrombotic risk; leaves open causal contribution and need for prospective trials.
Indices of acute in vivo platelet activation in response to cigarette smoking were sought in 10 healthy subjects. Judging by platelet aggregate ratio, platelet factor 4 and beta-thromboglobulin measurements, platelet activation took place from 10 to 30 min after smoking in most subjects. These signs correlated well with the results of scintigraphic studies showing signs of accumulation of 111-In-labelled platelets in the spleen in response to smoking.
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Schmidt et al. (1984) studied this question.
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