Key result
Higher triglyceride-glucose index linked to ~41% greater all-cause mortality risk per unit after TAVR.
Why the study?
The prognostic value of the triglyceride-glucose index in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement remains unknown.
Does a higher triglyceride-glucose (TyG) index predict increased all-cause mortality in patients with severe aortic stenosis undergoing TAVR?
Cohort (n=1,045)
No
Does a higher triglyceride-glucose (TyG) index predict increased all-cause mortality in patients with severe aortic stenosis undergoing TAVR?
Effect estimate: HR 1.41 (95% CI 1.03-1.93)
p-value: p=0.030
A higher triglyceride-glucose index is associated with increased all-cause mortality in patients with severe aortic stenosis undergoing TAVR, suggesting its utility as a prognostic marker.
BACKGROUNDS: The prognosis of the triglyceride-glucose (TyG) index, a validated surrogate marker for insulin resistance, in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) remains unknown. METHODS: This study consecutively enrolled patients diagnosed with severe AS who underwent TAVR in a Chinese tertiary hospital from March 2013 to September 2023. Participants were stratified based on the TyG index cut-off value. Cox proportional hazards regression models were utilized to explore the association between the TyG index and all-cause mortality, including an assessment of interactions between the TyG index and various covariates on mortality outcomes. RESULTS: = 0.002). CONCLUSIONS: A higher TyG index is significantly associated with an increased risk of all-cause mortality in AS patients after TAVR. These results underscore the importance of considering the TyG index in the prognostic evaluation of AS patients following TAVR.
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Fan et al. (2024) conducted a cohort in Severe aortic stenosis (n=1,045). Higher triglyceride-glucose (TyG) index vs. Lower triglyceride-glucose (TyG) index was evaluated on All-cause mortality (HR 1.41, 95% CI 1.03-1.93, p=0.030). A per-unit increase in the triglyceride-glucose index was associated with a 41% higher risk of all-cause mortality (HR 1.41) in patients with severe aortic stenosis after transcatheter aortic valve replacement.
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