Key result
Highest triglyceride-glucose index quartile linked to ~50% higher in-hospital mortality in aortic dissection.
Why the study?
The prognostic value of the triglyceride-glucose (TyG) index in patients with aortic dissection remains unclear.
Does a higher triglyceride-glucose (TyG) index predict increased in-hospital mortality in patients with aortic dissection?
Cohort (n=1,136)
No
Does a higher triglyceride-glucose (TyG) index predict increased in-hospital mortality in patients with aortic dissection?
Hazard Ratio: 1.5 (95% CI 1.066–2.111)
p-value: p=0.020
The TyG index is an independent predictor of in-hospital mortality in patients with aortic dissection, offering a potential tool for clinical risk stratification.
May refine in-hospital risk stratification in aortic dissection; extends TyG evidence but remains hypothesis-generating pending prospective validation.
Background The triglyceride-glucose (TyG) index, a novel surrogate marker of insulin resistance, has been linked to various cardiovascular diseases. While its role in aortic aneurysm and dissection has been studied, its prognostic value in patients with aortic dissection (AD) remains unclear. Methods In this retrospective cohort study, we screened 16,859 patients who underwent aortic computed tomography angiography (CTA) for chest pain at Tongji Hospital from 2012 to 2020. After exclusions, 1,136 patients with confirmed AD and complete clinical data were analyzed. The primary endpoint was in-hospital all-cause mortality. We used multivariable Cox regression models combined with propensity score matching (PSM) analysis to assess the association between TyG index and mortality risk. Subgroup analyses were conducted by surgical status and patient characteristics. Results Among the 1,136 patients, 291 (25.6%) died during hospitalization. Higher TyG index quartiles were significantly associated with increased mortality. In full adjusted models, patients in the highest TyG quartile (Q4) had a 76.8% increased mortality risk compared to Q1 (HR=1.500, 95% CI: 1.066–2.111, P=0.020). Importantly, this association remained robust after additional adjustment for dissection type and surgical status. Restricted cubic spline (RCS) analysis showed a linear relationship between TyG index and in-hospital mortality. Conclusions Our findings identify the TyG index as an independent predictor of in-hospital mortality in AD patients, underscoring its potential value for clinical risk stratification and prognosis assessment.
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Liu et al. (2026) conducted a cohort in Aortic dissection (n=1,136). Triglyceride-glucose (TyG) index vs. Lowest TyG quartile (Q1) was evaluated on In-hospital all-cause mortality (HR 1.500, 95% CI 1.066-2.111, p=0.020). The highest triglyceride-glucose index quartile was associated with increased in-hospital mortality compared to the lowest quartile in aortic dissection (HR 1.500; 95% CI 1.066-2.111; P=0.020).
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