Key result
Higher triglyceride-glucose index levels at admission were independently associated with an increased risk of in-hospital all-cause mortality (OR 1.27) among patients with acute myocardial infarction.
Why the study?
The study was conducted to investigate the association between admission triglyceride-glucose index levels and the risk of in-hospital adverse events, including all-cause mortality, in patients with acute myocardial infarction.
Is a higher triglyceride-glucose (TyG) index at admission associated with increased in-hospital mortality and adverse events in patients with acute myocardial infarction?
Cohort (n=3,458)
No
Is a higher triglyceride-glucose (TyG) index at admission associated with increased in-hospital mortality and adverse events in patients with acute myocardial infarction?
Answers are grounded in this paper and cite their sources.
Higher triglyceride-glucose index at admission is independently associated with increased in-hospital mortality and cardiogenic shock in patients with acute myocardial infarction, suggesting its potential as a prognostic biomarker.
OBJECTIVES: To investigate the association between triglyceride-glucose (TyG) index levels at hospital admission and the risk of in-hospital adverse events, including all-cause mortality, in patients with acute myocardial infarction (AMI). The primary hypothesis was that higher TyG index levels are associated with greater risk of adverse in-hospital outcomes. DESIGN: Retrospective cohort study. SETTING: Tertiary hospital inpatient care in China. The study included consecutively hospitalised patients with AMI between 1 August 2011 and 10 January 2022. PARTICIPANTS: A total of 3458 patients with AMI were included. The mean age was 60.8 years, and 78.4% were men. Patients were excluded if they had incomplete data for TyG index calculation or outcome ascertainment. INTERVENTIONS: No therapeutic intervention was assigned; the study was observational. TyG index was calculated using fasting triglycerides and fasting plasma glucose levels at admission. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was all-cause in-hospital mortality. Secondary outcomes included cardiogenic shock and fatal rapid arrhythmia. Outcomes were identified through standardised clinical records. RESULTS: Among 3458 patients, 375 (10.84%) died during hospitalisation, 236 (6.84%) developed cardiogenic shock and 147 (4.25%) experienced fatal rapid arrhythmia. After multivariable adjustment, higher TyG index levels were significantly associated with increased odds of all-cause mortality (OR, 1.27; 95% CI, 1.02 to 1.57; p<0.05) and cardiogenic shock (OR, 1.54; 95% CI, 1.22 to 1.94; p<0.001). When categorised into quartiles, patients in the highest quartile (Q4) had greater odds of mortality (OR, 1.71; 95% CI, 1.10 to 2.65; p<0.05) and cardiogenic shock (Q2: OR, 2.18; 95% CI, 1.39 to 3.45; Q3: OR, 1.71; 95% CI, 1.06 to 2.77; Q4: OR, 2.81; 95% CI, 1.70 to 4.67; all p<0.05 vs Q1). Restricted cubic spline analysis confirmed a linear association between the TyG index and both primary and secondary outcomes. CONCLUSION: Higher TyG index levels at admission are independently associated with an increased risk of all-cause mortality and cardiogenic shock among patients hospitalised for AMI. These findings suggest that the TyG index may serve as a useful prognostic biomarker for risk stratification in this population. Further prospective studies are warranted to validate its clinical utility.
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Yuan et al. (2025) conducted a cohort in Acute myocardial infarction (AMI) (n=3,458). Triglyceride-glucose (TyG) index vs. Lower TyG index levels was evaluated on All-cause in-hospital mortality (OR 1.27, 95% CI 1.02 to 1.57, p=0.031). Higher triglyceride-glucose index levels at admission were independently associated with an increased risk of in-hospital all-cause mortality (OR 1.27) among patients with acute myocardial infarction.
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