What question did this study set out to answer?

To assess the prognostic value of the triglyceride-glucose (TyG) index for predicting adverse cardiovascular outcomes in patients presenting with type 2 diabetes mellitus and acute myocardial infarction.

February 11, 2021Cardiovascular DiabetologyOpen Access

Predictive effect of triglyceride‑glucose index on clinical events in patients with type 2 diabetes mellitus and acute myocardial infarction: results from an observational cohort study in China

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Authors

YZYue ZhangUniversity of Alabama at Birmingham XDXiaosong DingCapital Medical University BHBing HuaBeijing Friendship Hospital

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Implication

Observational cohort study shows elevated triglyceride-glucose index predicts major adverse cardiovascular events in diabetic myocardial infarction patients, highlighting its prognostic value.

Key Points

To assess the prognostic value of the triglyceride-glucose (TyG) index for predicting adverse cardiovascular outcomes in patients presenting with type 2 diabetes mellitus and acute myocardial infarction.
Enrolled 1,932 consecutive patients with type 2 diabetes mellitus and acute myocardial infarction in an observational cohort in China, stratified into tertiles by TyG index.
Calculated the TyG index using fasting triglyceride and glucose levels: ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL) / 2].
Evaluated the incidence of major adverse cardiac and cerebral events (MACCEs) using competing risk regression and receiver operating characteristic (ROC) analysis.
Higher TyG index significantly increased the risk of composite MACCEs [effect size 2.32 (95% CI, 1.92–2.80), p < 0.001], cardiovascular death [2.71 (95% CI, 1.92–3.83), p < 0.001], non-fatal MI [2.02 (95% CI, 1.32–3.11), p = 0.001], rehospitalization [2.42 (95% CI, 1.81–3.24), p < 0.001], and revascularization [2.41 (95% CI, 1.63–3.55), p < 0.001].
TyG index predicted MACCEs with an area under the ROC curve of 0.604 (95% CI, 0.578–0.630, p < 0.001; cutoff value 9.30) and significantly improved baseline model discrimination (C-index: 0.685 [95% CI, 0.663–0.707], p < 0.001; IDI: 0.027, p < 0.001).

Cite This Study

Zhang et al. (2021) studied this question.

synapsesocial.com/papers/6a78d08ff8c4f0860701fc7f https://doi.org/10.1186/s12933-021-01236-3

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Implication

Observational cohort study shows elevated triglyceride-glucose index predicts major adverse cardiovascular events in diabetic myocardial infarction patients, highlighting its prognostic value.

Predictive effect of triglyceride‑glucose index on clinical events in patients with type 2 diabetes mellitus and acute myocardial infarction: results from an observational cohort study in China

Discussion

Member takes

Implication

Key Points

Cite This Study

Predictive effect of triglyceride‑glucose index on clinical events in patients with type 2 diabetes mellitus and acute myocardial infarction: results from an observational cohort study in China

Discussion

Member takes

Implication

Key Points

Cite This Study

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