Key result
A 1-unit increment in the Triglyceride-glucose index was associated with an 18% higher risk of major adverse cardiac and cerebrovascular events (aHR 1.18) in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
Why the study?
The triglyceride-glucose index, a surrogate marker of insulin resistance, could be a potential prognostic marker in acute coronary syndrome patients.
Does a higher Triglyceride-glucose index predict major adverse cardiac and cerebrovascular events in patients with acute coronary syndrome undergoing percutaneous coronary intervention?
Population
13,542 patients with ACS undergoing PCI
Comparison
TyG quartiles and per 1-unit increment
Design
Registry-based cohort study
Follow-up
Median 378 days
Authors
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TyG index may aid post-PCI risk stratification in ACS; leaves open incremental value and requires prospective validation.
Cohort (n=13,542)
No
Does a higher Triglyceride-glucose index predict major adverse cardiac and cerebrovascular events in patients with acute coronary syndrome undergoing percutaneous coronary intervention?
Hazard Ratio: 1.18 (95% CI 1.08–1.3)
p-value: p=<0.001
A higher Triglyceride-glucose index is an independent predictor of major adverse cardiac and cerebrovascular events in patients with acute coronary syndrome undergoing PCI, though this association is not significant in euglycemic patients.
Khalaji et al. (2024) conducted a cohort in Acute coronary syndrome (n=13,542). Triglyceride-glucose (TyG) index vs. Lower TyG index was evaluated on Major adverse cardiac and cerebrovascular events (MACCE) (aHR 1.18, 95% CI 1.08-1.30, p=<0.001). A 1-unit increment in the Triglyceride-glucose index was associated with an 18% higher risk of major adverse cardiac and cerebrovascular events (aHR 1.18) in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
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