June 26, 2026Journal of Cardiovascular Medicine
At 1 year, MACE incidence increased progressively across TyG index quartiles, with the highest risk observed in the fourth quartile compared with the first, primarily driven by spontaneous MI.
Why the study?
The prognostic relevance of the triglyceride-glucose index in large, demographically diverse populations undergoing PCI remains unestablished.
Does a higher triglyceride-glucose (TyG) index predict adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention?
Population
21 124 consecutive patients undergoing PCI at a high-volume tertiary care center in the US
Comparison
Higher quartiles of the TyG index vs lowest quartile
Design
Cohort study
Follow-up
1 year
Authors
Discussion
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Member takes
Overview
May inform post-PCI risk stratification in diverse cohorts; hypothesis-generating and requires prospective validation.
Structured PICO
Does a higher triglyceride-glucose (TyG) index predict adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention?
P
Population
21,124 consecutive patients undergoing percutaneous coronary intervention (PCI) from 2012 to 2022 at a high-volume tertiary care center in the United States.
I
Intervention
Higher quartiles of the triglyceride-glucose (TyG) index
C
Comparator
Lowest quartile of the triglyceride-glucose (TyG) index
O
Outcome
Major adverse cardiovascular events (MACE), consisting of all-cause mortality, myocardial infarction (MI), or stroke at 1 yearcomposite
The triglyceride-glucose index is a significant predictor of 1-year major adverse cardiovascular events, particularly spontaneous MI, in a diverse US population undergoing PCI.
Cite This Study
Muro et al. (2026) studied this question.