Key result
Elevated triglyceride-glucose index linked to ~71% higher in-hospital and ICU mortality in AMI-CA.
Why the study?
The study aimed to clarify the link between the triglyceride-glucose index and the incidences and prognoses of cardiac arrest following acute myocardial infarction.
Does an elevated triglyceride-glucose (TyG) index correlate with the incidence and prognosis of cardiac arrest following acute myocardial infarction?
Observational (n=5,208)
Yes
Does an elevated triglyceride-glucose (TyG) index correlate with the incidence and prognosis of cardiac arrest following acute myocardial infarction?
Effect estimate: OR 1.711 (95% CI 1.152-2.540)
p-value: p=0.008
May inform risk stratification in AMI with cardiac arrest; hypothesis-generating and requires prospective validation.
BACKGROUND: The triglyceride-glucose (TyG) index, renowned for its efficacy and convenience in assessing insulin resistance, has been validated as a reliable indicator for various cardiovascular conditions. The current study aims for clarifying the link of TyG with the incidences and prognoses of cardiac arrest (CA) following acute myocardial infarction (AMI). METHODS: Our analysis is a multicenter, retrospective study utilizing data from the Medical Information Mart for Intensive Care IV and the eICU Collaborative Research Database. Patients with AMI for whom TyG could be calculated within the first 24 h after admission were included. The main endpoints were in-hospital and ICU mortalities. Correlations between TyG and outcomes were evaluated using logistic regression models, restricted cubic splines (RCS), as well as correlation and linear analyses. Overlap weighting (OW), inverse probability of treatment weighting (IPTW), and propensity score matching (PSM) methodologies were utilized to balance the cohorts, thereby minimizing potential biases. Subgroup analyses were performed in accordance with identified modifiers. RESULTS: , and those with hypertension. CONCLUSIONS: Elevated TyG levels were found to apparently correlate with higher prevalence and adverse outcomes regarding CA in patients with AMI. Our findings point a fresh insight into the significance of the TyG in critically ill coronary conditions.
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Liu et al. (2025) conducted an observational in Acute myocardial infarction (n=5,208). Triglyceride-glucose (TyG) index vs. Lower TyG index was evaluated on In-hospital mortality in AMI-CA patients (per 1 unit increase in TyG index) (OR 1.711, 95% CI 1.152-2.540, p=0.008). Elevated triglyceride-glucose index was significantly associated with increased risks of in-hospital (OR 1.711) and ICU mortality in patients with acute myocardial infarction complicated by cardiac arrest.
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