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January 2, 2025Scientific ReportsOpen Access

Higher TyG index linked to ~23% higher 30-day mortality in AMI patients after PCI.

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Why the study?

The connection between the triglyceride glucose (TyG) index and prognosis in acute myocardial infarction (AMI) patients after percutaneous coronary intervention (PCI) remains uncertain.

Does a higher triglyceride glucose (TyG) index predict increased all-cause mortality in adult patients with acute myocardial infarction following percutaneous coronary intervention?

Population

1410 AMI patients who received PCI

Comparison

Higher vs lower TyG index levels

Follow-up

12 months

Key result

A higher Triglyceride glucose (TyG) index was significantly associated with an increased risk of 30-day all-cause mortality (HR 1.233) in patients with acute myocardial infarction following percutaneous coronary intervention.

Authors

GYGuang YangZHZilun HuangSWShanjie Wang

Discussion

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Member takes

Overview

May refine post-PCI AMI risk stratification; leaves open prospective validation before clinical use.

Study Design

Type

Cohort (n=1,410)

Multicenter

No

Structured PICO

Does a higher triglyceride glucose (TyG) index predict increased all-cause mortality in adult patients with acute myocardial infarction following percutaneous coronary intervention?

P
Population
1,410 adult patients with acute myocardial infarction who underwent percutaneous coronary intervention, with an average age of 66 years and 35.1% female, followed for up to 12 months.
E
Exposure
High Triglyceride glucose (TyG) index (evaluated continuously and in quartiles)
C
Comparator
Lower Triglyceride glucose (TyG) index (Q1: 6.60-8.67)
O
Outcome
All-cause mortality at 30 days and 12 monthshard clinical

Main Result

Hazard Ratio: 1.233 (95% CI 1.086–1.399)

p-value: p=0.001

An elevated triglyceride glucose (TyG) index is an independent predictor of 30-day and 12-month all-cause mortality in patients with acute myocardial infarction undergoing percutaneous coronary intervention.

Limitations

  • Missing clinical information such as frequency of procedures, number of stents implanted, and extent of stenosis.
  • Alterations in the TyG index during follow-up were not monitored.
  • Usage of lipid-lowering or glucose-lowering drugs was not documented, potentially influencing TG and FBG levels.
  • Did not account for other variables like exercise habits, dietary information, or cardiorespiratory fitness.
  • Did not evaluate A1C values and glycemic control, which may be a confounder.
  • Missing clinical information (procedure frequency, stents implanted, stenosis extent)
  • Alterations in TyG index during follow-up not monitored
  • Usage of lipid-lowering or glucose-lowering drugs not documented
  • Model did not account for exercise habits, dietary information, or cardiorespiratory fitness
  • Lack of A1C values and glycemic control evaluation

Cite This Study

Yang et al. (2025) conducted a cohort in Acute myocardial infarction following percutaneous coronary intervention (n=1,410). Triglyceride glucose (TyG) index vs. Lower TyG index was evaluated on 30-day all-cause mortality (HR 1.233, 95% CI 1.086-1.399, p=0.001). A higher Triglyceride glucose (TyG) index was significantly associated with an increased risk of 30-day all-cause mortality (HR 1.233) in patients with acute myocardial infarction following percutaneous coronary intervention.

synapsesocial.com/papers/6a21cffbaa3e25cc2f7c34e5https://doi.org/10.1038/s41598-024-81432-9
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