Key result
NGS and GWAS genetic markers effectively diagnose SCD predisposition to enable targeted prevention.
Why the study?
Sudden cardiac death remains a significant clinical challenge, motivating the exploration of molecular genetic markers to identify predispositions and implement personalized preventive strategies.
Can molecular genetic markers be used to diagnose a predisposition to sudden cardiac death?
Can molecular genetic markers be used to diagnose a predisposition to sudden cardiac death?
Molecular genetic testing using modern methods like NGS and GWAS holds promise for identifying individuals predisposed to sudden cardiac death, enabling targeted preventive strategies.
Answers are grounded in this paper and cite their sources.
Genetic screening for SCD predisposition should not yet change practice; leaves open need for prospective validation of NGS/GWAS markers.
Sudden cardiac death (SCD) continues to be a relevant and significant problem in modern medicine. Modern trends in medicine are associated with the widespread introduction of personalized, preventive strategies aimed at correcting risk factors for pathology, identifying predispositions to it and conducting prevention before the development of clinical symptoms. Nowadays, a huge number of studies of the molecular genetic basis of SCD are conducted. Studies of case-control design using routine methods of molecular genetic research continue to be popular. Research using modern, highly effective methods (sequencing of the next generation (NGS), full-genome associative studies (GWAS)) have become more frequent. The molecular genetic markers of SCD found in such studies can be used effectively to diagnose a predisposition to SCD and prevent its development in persons with known and unknown cardiac pathology.
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Иванова et al. (2018) conducted a review in Sudden cardiac death. Molecular genetic markers was evaluated. Molecular genetic markers identified through NGS and GWAS can effectively diagnose a predisposition to sudden cardiac death and prevent its development.
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