Key result
Concomitant diabetes and hypertension are linked to increased arterial stiffness, while HbA1c shows no correlation.
Why the study?
The impact of glycemic control on macrovascular complications and arterial stiffness in T2D, and the extent of the additive effect of hypertension, remains unclear.
Does glycemic control and concomitant hypertension affect arterial stiffness in patients with Type II diabetes?
Observational (n=109)
Does glycemic control and concomitant hypertension affect arterial stiffness in patients with Type II diabetes?
p-value: p=<0.001
Concomitant diabetes and hypertension significantly increase the risk of arterial stiffness, while glycemic control alone does not correlate with arterial stiffness in T2D patients.
Concomitant diabetes and hypertension was associated with arterial stiffness; leaves open glycemic control's independent role in this cross-sectional analysis.
PURPOSE: The impact of glycemic control on macrovascular complications and arterial stiffness in type II diabetes (T2D), as well as the extent of additive effect of hypertension, is unclear. The aims of this study were to investigate the impact of glycemic control on the cardio-ankle vascular index (CAVI), an indicator of arterial stiffness, and to determine the relative risk of concomitant diabetes and hypertension with arterial stiffness. METHODS: One hundred and nine participants were enrolled and classified as non-diabetes (n= 37) and diabetes (n=72); the diabetic group was further identified as controllable and uncontrollable T2D depending on their hemoglobin A1c (HbA1c) levels. Univariate and multiple regression analyses were used to assess the association between CAVI and glycemic control status and hypertension. Relative risk analysis for abnormal CAVI with exposure to diabetes and hypertension was investigated. RESULTS: <0.001). CONCLUSION: This study demonstrates that HbA1c as well as fasting blood sugar levels in diabetic participants do not correlate with arterial stiffness. Concomitant diabetes and hypertension significantly increase the risk of arterial stiffness.
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Nuamchit et al. (2020) conducted an observational in Type II Diabetes and Hypertension (n=109). Type II diabetes and concomitant hypertension (exposure) vs. Non-diabetes was evaluated on Cardio-ankle vascular index (CAVI) (p=<0.001). Concomitant diabetes and hypertension significantly increased the risk of arterial stiffness (P<0.001), while HbA1c and fasting blood sugar levels did not correlate with arterial stiffness.
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