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July 30, 2012Journal of Diabetes InvestigationOpen Access

Increased arterial stiffness is closely associated with hyperglycemia and improved by glycemic control in diabetic patients

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Why the study?

Does glycemic control improve arterial stiffness measured by CAVI in patients with early-stage diabetes mellitus?

Structured PICO

Does glycemic control improve arterial stiffness measured by CAVI in patients with early-stage diabetes mellitus?

P

Population

95 subjects total: 52 early-staged diabetes mellitus (DM) patients (duration <5 years, no microangiopathies) and 43 age-matched non-diabetic (NDM) subjects. A subset of 36 DM patients were hospitalized for 2 weeks for glycemic control.

I

Intervention

Glycemic control (2-week hospitalization to treat hyperglycemia)

C

Comparator

Age-matched non-diabetic subjects (for cross-sectional comparison) and baseline values (for longitudinal comparison)

O

Outcome

Arterial stiffness estimated by cardio-ankle vascular index (CAVI)surrogate

Arterial stiffness, measured by CAVI, is elevated in early-stage diabetes and can be improved with glycemic control.

Discussion

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Implication

Glycemic control may improve arterial stiffness in early DM; hypothesis-generating and requires randomized confirmation before practice change.

Cite This Study

Ibata et al. (2012) studied this question.

synapsesocial.com/papers/6a7cddff033ca1e0093e1522 https://doi.org/10.1111/j.2040-1124.2012.00229.x

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetescross-sectional · 2011 · 128 citations
2Relationship of Cardio-Ankle Vascular Index (CAVI) to Carotid and Coronary Arteriosclerosiscross-sectional · 2008 · 150 citations
3Cardio-Ankle Vascular Index is Independently Associated with the Severity of Coronary Atherosclerosis and Left Ventricular Function in Patients with Ischemic Heart Diseasecross-sectional · 2010 · 99 citations
4Improvement of cardio-ankle vascular index by glimepiride in type 2 diabetic patientsRCT · 2010 · 76 citations
5A Novel Blood Pressure-independent Arterial Wall Stiffness Parameter; Cardio-Ankle Vascular Index (CAVI)cross-sectional · 2006 · 952 citations