Postchallenge hyperglycaemic spike associate with arterial stiffness

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Why the study?

Is postchallenge hyperglycaemia associated with arterial stiffness in healthy subjects without type 2 diabetes?

Population

40 healthy subjects without clinical diagnosis of type 2 diabetes recruited from a physical examination in…

Design

Cross-sectional

Authors

Discussion

Postchallenge hyperglycaemia was associated with arterial stiffness in nondiabetics; leaves open causality and need for prospective trials.

Is postchallenge hyperglycaemia associated with arterial stiffness in healthy subjects without type 2 diabetes?

Population

40 healthy subjects without clinical diagnosis of type 2 diabetes recruited from a physical examination in 2005.

Intervention

Oral glucose tolerance test (OGTT) to assess postchallenge hyperglycaemic spike (glucose levels at 60 min and glucose area under the curve).

Outcome

Cardio-ankle vascular index (CAVI) as a measure of arterial stiffness.surrogate

In subjects without type 2 diabetes, postchallenge hyperglycaemic spikes are independently associated with increased arterial stiffness.

Huang et al. (2007) studied this question.

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Postchallenge hyperglycaemia was associated with arterial stiffness in nondiabetics; leaves open causality and need for prospective trials.