Key result
Fasting plasma glucose, postprandial glucose, and HbA1c were positively associated with arterial stiffness measures like baPWV (HbA1c β 0.266), an association maintained only in subjects with type 2 diabetes.
Why the study?
Are glycemic markers (FPG, PG, HbA1c) associated with arterial stiffness (CAVI, baPWV) in Caucasian adults with intermediate cardiovascular risk?
Cross-Sectional (n=2,233)
Yes
Are glycemic markers (FPG, PG, HbA1c) associated with arterial stiffness (CAVI, baPWV) in Caucasian adults with intermediate cardiovascular risk?
Effect estimate: β 0.266 (95% CI 0.172 to 0.359)
p-value: p=<0.01
In Caucasian adults with intermediate cardiovascular risk, glycemic markers are positively associated with arterial stiffness, but this association is driven primarily by subjects with established type 2 diabetes mellitus.
Suggests glycemic control primarily impacts vascular compliance in established type 2 diabetes; leaves.
BACKGROUND: Effect of prediabetes and normal glucose on arterial stiffness remains controversial. The primary aim of this study was to investigate the relationship of fasting plasma glucose (FPG), postprandial glucose (PG) and glycosylated haemoglobin (HbA1c) with brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) in Caucasian adults. The secondary aim was to analyse this relationship by glycaemic status. METHODS: Cross-sectional study. Setting: Primary care. Participants: 2,233 subjects, 35-74 years. Measures: FPG (mg/dL) and HbA1c (%) of all subjects were measured using standard automated enzymatic methods. PG (mg/dL) was self-measured at home two hours after meals (breakfast, lunch and dinner) for one day using an Accu-chek ® glucometer. CAVI was measured using a VaSera VS-1500® device (Fukuda Denshi), and baPWV was calculated using a validated equation. RESULTS: CAVI and baPWV values were significantly higher in subjects with diabetes mellitus than in glucose normal and prediabetes groups (p<0.001). FPG, PG and HbA1c were positively associated with CAVI and baPWV. The β regression coefficient for: HbA1c was 0.112 (CI 95% 0.068 to 0.155) with CAVI, 0.266 (CI 95% 0.172 to 0.359) with baPWV; for PG was 0.006 (CI 95% 0.004 to 0.009 and for FPG was 0.005 (CI 95% 0.002 to 0.008) with baPWV; and for PG was 0.002 (CI 95% 0.001 to 0.003) and 0.003 (CI 95% 0.002 to 0.004) with CAVI (p<0.01 in all cases). When analysing by hyperglycaemic status, FPG, PG and HbA1c were positively associated with CAVI and baPWV in subjects with type 2 diabetes mellitus. CONCLUSION: FPG, PG and HbA1c show a positive association with CAVI and baPWV, in Caucasian adults with intermediate cardiovascular risk factors. When analysing by hyperglycaemic status, the association is only maintained in subjects with type 2 diabetes mellitus. TRIAL REGISTRATION: Clinical Trials.gov Identifier: NCT01428934. Registered 2 September 2011. Retrospectively registered. Last updated September 8, 2016.
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Gómez‐Sánchez et al. (2017) conducted a cross-sectional in Intermediate cardiovascular risk (n=2,233). Glycemic markers (FPG, PG, HbA1c) vs. Normal glucose metabolism and prediabetes was evaluated on Relationship of FPG, PG and HbA1c with CAVI and baPWV (β 0.266, 95% CI 0.172 to 0.359, p=<0.01). Fasting plasma glucose, postprandial glucose, and HbA1c were positively associated with arterial stiffness measures like baPWV (HbA1c β 0.266), an association maintained only in subjects with type 2 diabetes.
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