Key result
Long-term BMI trends linked to increased arterial stiffening in adult males but not females.
Why the study?
Obesity and hypertension contribute to arterial stiffness, but sex differences in the impact of cumulative long-term burden and trends of BMI and BP since childhood on adult arterial stiffness needed investigation.
Does the long-term burden and trend of BMI and BP from childhood to adulthood impact arterial stiffness differently in males and females?
Population
1553 individuals aged 6-15 years examined 4 or more times for BMI and BP since childhood
Comparison
Long-term burden and trends of BMI and BP from childhood to adulthood evaluated by sex
Design
Longitudinal cohort study
Follow-up
30 years
Authors
Loading...
Incremental BMI trends linked to stiffness only in males; leaves open sex-specific prevention trials.
Cohort (n=1,553)
Does the long-term burden and trend of BMI and BP from childhood to adulthood impact arterial stiffness differently in males and females?
p-value: p=0.019
Long-term increases in BMI from childhood to adulthood are associated with increased arterial stiffness in men but not women, whereas cumulative blood pressure burden increases stiffness in both sexes.
Liao et al. (2020) conducted a cohort in Arterial stiffness (n=1,553). Long-term burden and trends of BMI and blood pressure was evaluated on Brachial-ankle pulse wave velocity (baPWV) in adulthood (p=0.019). Long-term trends in body mass index (incremental AUC) were associated with an increased risk of arterial stiffening in adult males but not females (p=0.019 for interaction).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: