Status of β1-Adrenoceptor Signal Transduction System in Cardiac Hypertrophy and Heart Failure

Figures

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  Fig. 1.. Acute and chronic effects of the sympathetic nervous system on β-adrenoceptor-mediated signal transduction components. NE, norepinephrine; EPI, epinephrine; Gs-Proteins, stimulatory guanine nucleotide proteins; ↑, increased.

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  Fig. 2.. General characteristics and ventricular function in rats at 4 and 24 weeks due to pressure overload (PO) after occluding the abdominal aorta. Data are based on the results described in our paper —Journal of Applied Physiology. 2007; 102: 978–984 [42]. LVDP, left ventricle developed pressure; LVEDP, left ventricle end diastolic pressure; ± dP/dt, rates of rise and decline of ventricle pressures. *p < 0.05 versus respective sham.

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  Fig. 3.. Effects of isoproterenol (ISO) on ventricular developed pressure and [Ca2+]𝐢 in cardiomyocytes at 4 and 24 weeks due to pressure overload (PO) in rats. Data are based on the results described in our paper —Journal of Applied Physiology. 2007; 102: 978–984 [42]. Con, control; LVDP, left ventricle developed pressure. *p < 0.05 versus respective sham.

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  Fig. 4.. Ventricular B𝐦𝐚𝐱 (maximal number of binding) and K𝐝 (dissociation constant) values for β1-adrenoceptors and effect of isoproterenol (ISO) on adenylyl cyclase activity at 4 and 24 weeks due to pressure overload (PO) in rats. Data are based on the results described in our paper — Journal of Applied Physiology. 2007; 102: 978–984 [42]. *p < 0.05 versus respective sham.

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  Fig. 5.. General characteristics and ventricular function in rats at 4 and 24 weeks due to volume overload (VO) after the aortocaval shunt. Data are based on the results described in our paper — Journal of Applied Physiology. 2007; 102: 978–984 [42]. LVDP, left ventricle developed pressure; LVEDP, left ventricle end diastolic pressure; ± dP/dt, rates of rise and decline of ventricle pressure. *p < 0.05 versus respective sham.

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  Fig. 6.. Effects of isoproterenol (ISO) on left ventricular developed pressure (LVDP) in rats and [Ca2+]𝐢 in cardiomyocytes at 4 and 24 weeks due to volume overload in rats. Data are based on the results described in our paper —Journal of Applied Physiology. 2007; 102: 978–984 [42]. LVDP, left ventricle developed pressure; Con, control; VO, volume overload. *p < 0.05 versus respective sham.

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  Fig. 7.. Ventricular Bmax (maximal number of binding) and Kd (dissociation constant) values for β1-adrenoceptors and effect of isoproterenol (ISO) on adenylyl cyclase activity at 4 and 24 weeks due to volume overload (VO) in rats. Data are based on the results described in our paper —Journal of Applied Physiology. 2007; 102:978–984 [42]. *p < 0.05 versus respective sham.