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October 9, 2014British Journal of PharmacologyOpen Access

Biased β2‐adrenoceptor signalling in heart failure: pathophysiology and drug discovery

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Why the study?

Does a combination of a Gs-biased β2-adrenoceptor agonist and a β1-adrenoceptor antagonist improve outcomes in heart failure compared to traditional therapies?

Population

Heart failure (including animal models)

Comparison

Combination of a Gs-biased β2-adrenoceptor… vs Traditional heart failure therapies

Design

Review

Authors

AWAnthony Yiu‐Ho WooYSYing SongRXRui‐Ping Xiao

Discussion

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Member takes

Overview

Does not support clinical use; hypothesis-generating for biased β-adrenoceptor targeting in heart failure.

Structured PICO

Does a combination of a Gs-biased β2-adrenoceptor agonist and a β1-adrenoceptor antagonist improve outcomes in heart failure compared to traditional therapies?

P
Population
Heart failure (including animal models)
I
Intervention
Combination of a Gs-biased β2-adrenoceptor agonist and a β1-adrenoceptor antagonist
C
Comparator
Traditional heart failure therapies
O
Outcome
Cardiac remodelling and cardiomyocyte contractility

This review highlights the pathogenic role of Gi-biased β2-adrenoceptor signalling in heart failure and proposes a novel combination therapy targeting Gs-biased β2 and β1 receptors.

Cite This Study

Woo et al. (2014) studied this question.

synapsesocial.com/papers/6a1c02baea84844e355f4fa1https://doi.org/10.1111/bph.12965
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1β‐adrenergic receptor signalling and its functional consequences in the diseased heart2016 · 114 citations
  2. 2Cardiac β-Adrenoceptor Signaling: The New Insight on An Old Target in the Therapy of Cardiovascular Disease2022 · 7 citations
  3. 3Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade2016 · 92 citations
  4. 4Molecular signaling of G‐protein‐coupled receptor in chronic heart failure and associated complications2019 · 26 citations
  5. 5Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment2006 · 73 citations