Why the study?
To investigate clinical and preclinical data exhibiting the molecular mechanisms by which altered levels of GRK change cardiac activity during heart failure.
Design
Review of clinical and preclinical data
Key result
Review of clinical and preclinical data highlights how altered levels of G-protein-coupled receptor kinases (GRK2 and GRK5) change cardiac activity and signaling during heart failure.
Authors
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Altered GRK2/5 levels may identify novel HF targets; leaves open the need for clinical validation trials.
This review summarizes the molecular mechanisms of G-protein-coupled receptor signaling and the pathological role of GRK2 and GRK5 in chronic heart failure.
Altamish et al. (2019) conducted a review in chronic heart failure. Review of clinical and preclinical data highlights how altered levels of G-protein-coupled receptor kinases (GRK2 and GRK5) change cardiac activity and signaling during heart failure.