Key result
In chronic heart failure, cardiac β-adrenoceptor function decreases, with β1-adrenoceptors selectively decreasing in dilated cardiomyopathy while both β1 and β2 decrease in other forms.
Design
Review
Authors
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Suggests caution with nonselective β-blockade in dilated cardiomyopathy; leaves open compensatory role of preserved β2-adrenoceptors.
The differential regulation of cardiac β1- and β2-adrenoceptors in various forms of heart failure suggests that β2-adrenoceptors may play a compensatory role in maintaining contractility in certain conditions like dilated cardiomyopathy.
Khamssi et al. (1990) conducted a review in Heart failure. Cardiac β1- and β2-adrenoceptor stimulation was evaluated. In chronic heart failure, cardiac β-adrenoceptor function decreases, with β1-adrenoceptors selectively decreasing in dilated cardiomyopathy while both β1 and β2 decrease in other forms.
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