September 1, 1988Journal of Cardiovascular Pharmacology
α-Adrenoceptors and α -Adrenoceptor-Mediated Positive Inotropic Effects in Failing Human Myocardium
Population
Human myocardial tissue from 21 patients with moderate and severe heart failure.
Comparison
In vitro stimulation with phenylephrine… vs Comparison between moderate and severe heart…
Design
Preclinical
Authors
Discussion
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Implication
Does not support altering HF therapies from animal data; leaves open compensatory alpha-adrenoceptor role pending human studies.
Structured PICO
P
Population
Human myocardial tissue from 21 patients with moderate (NYHA class II-III, n=12) and severe (NYHA class IV, n=9) heart failure.
I
Intervention
In vitro stimulation with phenylephrine (in the presence of propranolol), isoprenaline, and Ca2+
C
Comparator
Comparison between moderate (NYHA II-III) and severe (NYHA IV) heart failure tissue
O
Outcome
Number of cardiac alpha- and beta-adrenoceptors and their mediated positive inotropic effectssurrogate
In failing human myocardium, beta-adrenoceptors are downregulated with increasing severity of heart failure, whereas alpha-adrenoceptors and their inotropic effects remain unchanged.
Cite This Study
Böhm et al. (1988) studied this question.