Why the study?
How does heart failure affect the myocardial contractile response to various positive inotropic agents in human papillary muscle strips?
Population
Papillary muscle strips from healthy and failing human hearts
Comparison
Positive inotropic agents vs Healthy human heart papillary muscle strips
Design
Preclinical
Authors
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May support ouabain preference in HF models; leaves open translation to human therapy.
How does heart failure affect the myocardial contractile response to various positive inotropic agents in human papillary muscle strips?
Unlike beta-adrenoceptors, cardiac glycoside receptors are not down-regulated in failing human myocardium, preserving the contractile response to ouabain.
Erland Erdmann (2008) studied this question.
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