Key result
Cyclic AMP-dependent agents showed significantly decreased inotropic actions but relatively preserved relaxant effects in myopathic human myocardium compared with control muscle.
Why the study?
Do cyclic AMP-dependent agents maintain their relaxation effects despite attenuated inotropic effects in myopathic human myocardium compared to controls?
Population
54 control and 59 myopathic human ventricular trabeculae from patients with end-stage heart failure and…
Comparison
Cyclic AMP-dependent agents and cyclic… vs Control human ventricular trabeculae without…
Design
Preclinical
Authors
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Suggests lusitropic targeting may warrant study in HF; leaves open clinical relevance of cAMP agents.
Do cyclic AMP-dependent agents maintain their relaxation effects despite attenuated inotropic effects in myopathic human myocardium compared to controls?
Cyclic AMP-dependent agents maintain their lusitropic effects in end-stage heart failure myocardium despite a severely attenuated inotropic response.
Gutstein et al. (1996) studied End-stage heart failure (n=113). Cyclic AMP-dependent agents (isoproterenol, isobutylmethylxanthine, milrinone) vs. Control myocardium was evaluated on Inotropic and relaxation response (percentage change from baseline). Cyclic AMP-dependent agents showed significantly decreased inotropic actions but relatively preserved relaxant effects in myopathic human myocardium compared with control muscle.
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