Population
Human ventricular preparations isolated from 5 non-failing and 8 explanted failing hearts with end-stage…
Comparison
alpha 1-Adrenoceptor agonist and beta… vs Non-failing human ventricular preparations
Design
Preclinical
Authors
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Supports impaired receptor-effector coupling in end-stage HF; leaves open downstream modulation as a therapeutic target.
In end-stage heart failure, the positive inotropic effects mediated by alpha 1- and beta 2-adrenoceptors are significantly reduced, likely due to impaired receptor-effector coupling rather than just receptor downregulation.
Steinfath et al. (1992) studied this question.
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