In human heart failure, β-adrenoceptor downregulation leads to reduced inotropic response in ventricular but not atrial myocardium, suggesting a receptor reserve in the atria.
No takes yet. Share an insight, caveat, or question.
Indicates atrial β-adrenoceptor reserve may preserve inotropy in HF; hypothesis-generating, requires human validation before any clinical consideration.
Schwinger et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: