Key result
TAVR cuts 30-day mortality ~21% vs SAVR, alongside fewer strokes and AKI.
Why the study?
Patients with aortic stenosis undergoing surgical valve replacement did not have encouraging outcomes, prompting a comparison of risk factors between transcatheter and surgical valve replacement.
Does TAVR improve procedural and 30-day safety outcomes compared to SAVR in patients with aortic stenosis?
Meta-Analysis (n=18,671)
Does TAVR improve procedural and 30-day safety outcomes compared to SAVR in patients with aortic stenosis?
TAVR is associated with significantly better 30-day safety outcomes, including lower all-cause mortality, stroke, acute kidney injury, and major bleeding, as well as shorter hospitalization compared to SAVR in patients with aortic stenosis.
Answers are grounded in this paper and cite their sources.
Supports TAVR preference in aortic stenosis for lower 30-day risks; reinforces Level 1 meta-analytic evidence versus SAVR.
Introduction: The advances and studies carried out in the area have shown that patients with aortic stenosis (AS) undergoing surgical valve replacement (SAVR) did not have encouraging outcomes. This study aims to compare the different risk factors in patients with AS undergoing transcatheter aortic valve replacement (TAVR) vs. SAVR, respectively, to offer options and more favorable results based on the results obtained in patients with these conditions. Conclusion: TAVR is superior to SAVR and significantly reduces the risks associated with all-cause mortality, stroke, AKI, and other clinical outcomes. Furthermore, additional research is regarding the long-term effects of transcatheter aortic valve replacement.
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Khan et al. (2025) conducted a meta-analysis in Aortic stenosis (n=18,671). Transcatheter aortic valve replacement (TAVR) vs. Surgical aortic valve replacement (SAVR) was evaluated on 30-day all-cause mortality (OR 0.79, 95% CI 0.63-1.00, p=0.05). Transcatheter aortic valve replacement reduced the odds of 30-day all-cause mortality, stroke, and acute kidney injury compared to surgical aortic valve replacement.
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