Why the study?
Do NSAIDs increase the risk of acute myocardial infarction in real-world use?
Do NSAIDs increase the risk of acute myocardial infarction in real-world use?
Real-world data confirms that all NSAIDs, including naproxen and celecoxib, are associated with an increased risk of acute myocardial infarction, particularly in the first month of use and at higher doses.
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Supports caution with all NSAIDs, especially early and at high doses; confirms MI risk elevation including naproxen in real-world data.
All NSAIDs, including naproxen, were found to be associated with an increased risk of acute myocardial infarction. Risk of myocardial infarction with celecoxib was comparable to that of traditional NSAIDS and was lower than for rofecoxib. Risk was greatest during the first month of NSAID use and with higher doses.
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Bally et al. (2017) studied this question.
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