Why the study?
Do specific NSAIDs increase the risk of acute myocardial infarction compared to no NSAID use?
Population
Patients from 16 observational studies published between 2000 and 2005 evaluating NSAIDs and myocardial…
Comparison
Traditional NSAIDs and selective… vs No NSAID use
Design
Meta-analysis
Authors
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Supports caution with diclofenac and rofecoxib in high CV-risk patients; extends meta-analytic evidence on NSAID-specific MI risks.
Do specific NSAIDs increase the risk of acute myocardial infarction compared to no NSAID use?
The risk of myocardial infarction varies among individual NSAIDs, with diclofenac and rofecoxib showing a significantly increased risk compared to non-use.
Hernández–Dı́az et al. (2006) studied this question.
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