Key result
OAC non-adherence in AF affects up to ~50%, driven by multimorbidity and polypharmacy.
Why the study?
Medication adherence is key for stroke prevention in atrial fibrillation, but compliance often decreases over time, leading to an increased risk of thromboembolism.
What are the risk factors for non-adherence to oral anticoagulants in patients with atrial fibrillation and how can it be prevented?
What are the risk factors for non-adherence to oral anticoagulants in patients with atrial fibrillation and how can it be prevented?
Non-adherence to oral anticoagulants in atrial fibrillation is highly prevalent (30-50%) and driven by factors such as age extremes, polypharmacy, and twice-daily dosing, highlighting the need for targeted adherence interventions.
Non-adherence to OACs in AF may warrant closer monitoring in high-risk patients; this review leaves optimal prevention strategies open.
Medication adherence is a key factor of effective stroke prevention in patients with atrial fibrillation receiving oral anticoagulant therapy. At the same time, patient compliance can significantly decrease over time, which leads to an increased thromboembolism risk. A number of studies have shown that a large number of patients receiving anticoagulant therapy are insufficiently adherent to therapy (according to various sources, from 30 to 50% of patients do not comply with the prescribed treatment regimen or interrupt therapy). Independent risk factors for non-compliance include younger age, old age, prior stroke, male sex, multimorbidity, polypharmacy. The risk of decreased compliance with double drug intake compared to single one is noted separately. The review aim is to study the risk factors for non-adherence to oral anticoagulants in patients with atrial fibrillation and possible measures for its prevention.
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Феликов et al. (2024) conducted a review in Atrial fibrillation. Oral anticoagulant therapy was evaluated on Non-adherence to oral anticoagulant therapy. Non-adherence to oral anticoagulant therapy in atrial fibrillation patients ranges from 30% to 50%, driven by risk factors like age extremes, prior stroke, male sex, multimorbidity, and polypharmacy.
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