Key result
Chemical adherence testing links medication nonadherence to higher BP, more prescribed antihypertensives, and younger age.
Why the study?
What is the prevalence of nonadherence to antihypertensive medications as assessed by chemical adherence testing?
Meta-Analysis
What is the prevalence of nonadherence to antihypertensive medications as assessed by chemical adherence testing?
Chemical adherence testing reveals that nonadherence to antihypertensives is associated with higher blood pressure, more prescribed medications, and younger age, though data on diverse populations is lacking.
Supports chemical adherence testing in resistant hypertension; extends age and polypharmacy associations but leaves generalizability open.
of 94.6% and 95.6%, respectively). Nonadherent patients had higher blood pressure and were prescribed more antihypertensive medications, whilst participant age showed an inverse relationship with prevalence of nonadherence. Key relevant sociodemographic factors were often not reported, limiting the understanding of CAT use in diverse populations. In order to support behavior change interventions to address medication nonadherence in underserved groups, future research should recruit diverse populations to inform equitable implementation. International Prospective Register of Systematic Reviews CRD42024505602.
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Highton et al. (2025) conducted a meta-analysis in Antihypertensive medication nonadherence. Chemical Adherence Testing (CAT) was evaluated on Prevalence of nonadherence. Chemical adherence testing revealed that nonadherent patients had higher blood pressure and were prescribed more antihypertensive medications, while age was inversely related to nonadherence.
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