Key result
Increased periodic repolarization dynamics identifies NICM patients who derive mortality benefit from prophylactic ICDs.
Why the study?
It was unknown whether periodic repolarization dynamics could identify patients with nonischemic cardiomyopathy who benefit from prophylactic ICD implantation.
Observational
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for PRD-guided ICD selection in nonischemic cardiomyopathy; prospective validation required before practice change.
BACKGROUND: Identification of patients with nonischemic cardiomyopathy who may benefit from prophylactic implantation of a cardioverter-defibrillator. We hypothesized that periodic repolarization dynamics (PRD), a marker of repolarization instability associated with sympathetic activity, could be used to identify patients who will benefit from prophylactic implantable cardioverter defibrillator (ICD) implantation. METHODS: as an exploratory cut-off value for ICD implantation. RESULTS: for interaction=0.01). CONCLUSIONS: Increased PRD identified patients with nonischemic cardiomyopathy in whom prophylactic ICD implantation led to significant mortality reduction.
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Boas et al. (2021) conducted an observational in Nonischemic cardiomyopathy. Prophylactic implantable cardioverter defibrillator (ICD) was evaluated on Mortality (p=0.01). Increased periodic repolarization dynamics identified patients with nonischemic cardiomyopathy in whom prophylactic ICD implantation led to significant mortality reduction (p for interaction=0.01).
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