Why the study?
Factors influencing susceptibility to doxorubicin respiratory toxicity are unclear, and the age-dependent physiological effects of doxorubicin on respiratory function remain underexplored.
Does doxorubicin reduce respiratory function and cardiorespiratory capacity in 2- and 20-month-old female Sprague-Dawley rats?
Population
2- and 20-month-old female Sprague-Dawley rats
Comparison
DOX treatment (20 mg/kg, IP) across 2- vs 20-month-old rats
Design
Preclinical animal study
Follow-up
48 hours
Key result
Acute doxorubicin treatment (20 mg/kg) negatively impacted respiratory muscle function and decreased exercise run time to fatigue in both 2- and 20-month-old female rats.
Authors
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Doxorubicin leaves hypoxic ventilation unchanged; leaves open whether diaphragm weakness drives clinical fatigue in treated patients.
Does doxorubicin reduce respiratory function and cardiorespiratory capacity in 2- and 20-month-old female Sprague-Dawley rats?
Acute doxorubicin treatment negatively impacts respiratory muscle function and exercise tolerance in both young and old female rats, with no age-dependent differences in diaphragm specific force production or mitochondrial drug concentration.
Reyes et al. (2026) studied Doxorubicin-induced respiratory muscle dysfunction. Doxorubicin vs. Prior to treatment was evaluated on Changes in respiratory function and cardiorespiratory capacity. Acute doxorubicin treatment (20 mg/kg) negatively impacted respiratory muscle function and decreased exercise run time to fatigue in both 2- and 20-month-old female rats.