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This research aims to understand the changes in spinal cord vasculature after cervical injury, focusing on microvascular loss and recovery timelines.

May 14, 2026Physiology

Histological and MRI evaluation of spinal cord vasculature after mid-cervical contusion in the adult rat

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Randomized trial characterizes vascular changes in adult rats after spinal cord injury, suggesting implications for therapies.

This research aims to understand the changes in spinal cord vasculature after cervical injury, focusing on microvascular loss and recovery timelines.
Adult male Sprague-Dawley rats underwent unilateral contusion at C4 with histological and MRI evaluations post-injury.
Fluorescent immunohistochemistry assessed vascular density using CD31 at three time points (1, 3, 10 DPI).
In vivo time-of-flight MRI quantified vascular density in defined regions around the injury.
Vascular density significantly reduced at the lesion site across all time points (1-10 DPI; p < 0.05).
Ipsilateral regions showed partial recovery of vascular density by 10 DPI, but remained lower than controls.
Magnetic resonance imaging confirmed reduced vascular signal consistent with CD31 measurements.

Diller et al. (2026) studied this question.

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