Key result
Experimental high-thoracic spinal cord transection in rats led to inward cerebrovascular remodeling and a 40% reduction in middle cerebral artery distensibility (P<0.05).
Why the study?
Does experimental high-thoracic spinal cord transection alter cerebrovascular structure and function in rats?
Population
Rats (n=25)
Comparison
Complete T3 spinal cord transection (T3-SCI) vs Sham injury
Design
Preclinical
Follow-up
7 weeks
Authors
Loading...
Rat SCI model suggests cerebrovascular stiffening; hypothesis-generating for human risk, no practice change yet.
Does experimental high-thoracic spinal cord transection alter cerebrovascular structure and function in rats?
Effect estimate: 40% reduction
p-value: p=<0.05
Experimental high-thoracic spinal cord injury induces profibrotic and hypertrophic inward remodeling in the largest cerebral artery, increasing stiffness.
Phillips et al. (2015) studied Spinal cord injury (n=25). Complete T3 spinal cord transection vs. Sham injury was evaluated on Middle cerebral artery distensibility (40% reduction, p=<0.05). Experimental high-thoracic spinal cord transection in rats led to inward cerebrovascular remodeling and a 40% reduction in middle cerebral artery distensibility (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: