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The study aims to define the effects of histamine on intestinal epithelial permeability and its role in stress-related intestinal disorders.

May 14, 2026Physiology

Effects of Histamine on Intestinal Epithelial Permeability of the Thirteen-lined Ground Squirrels

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Randomized trial examines histamine's impact on intestinal permeability in ground squirrels, suggesting stress role.

The study aims to define the effects of histamine on intestinal epithelial permeability and its role in stress-related intestinal disorders.
Five adult female thirteen-lined ground squirrels were examined after euthanasia.
Jejunal and colonic segments were mounted in the Ussing Chamber System to measure transepithelial resistance and permeability flux rates.
Histamine at two concentrations (100 uM and 1 mM) was applied to assess its impact on epithelial barrier function.
In colonic tissue, histamine significantly reduced transepithelial resistance (TER) with 1 mM showing substantial effects.
Histamine (1 mM) increased FITC-insulin flux rate in the colon, whereas 100 uM had no effect.
Histamine did not alter TER or FITC-insulin flux in the jejunum, and HRP flux remained unchanged.

Vandigo et al. (2026) studied this question.

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