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May 1, 1993AJP Heart and Circulatory Physiology

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade

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Population

Isolated porcine coronary venules

Comparison

Histamine with or without inhibitors vs Baseline permeability / absence of inhibitors

Design

Preclinical

Authors

YYYonggui YuanChinese Academy of SciencesHGHarris J. GrangerUniversity of SienaDZDavid C. ZawiejaMitchell Institute

Discussion

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Implication

Supports histamine-mediated coronary permeability mechanisms; hypothesis-generating for endothelial signaling in human cardiac edema.

Structured PICO

P
Population
Isolated porcine coronary venules
I
Intervention
Histamine (2.5, 5, and 10 microM) with or without inhibitors (NCDC, L-NMMA, LY 83583)
C
Comparator
Baseline permeability / absence of inhibitors
O
Outcome
Apparent permeability coefficient to albumin (Pa)surrogate

Histamine increases coronary venular permeability via a phospholipase C-NO synthase-guanylate cyclase signaling cascade in endothelial cells.

Cite This Study

Yuan et al. (1993) studied this question.

synapsesocial.com/papers/6a7e805eb2811efa75cd9b2ahttps://doi.org/10.1152/ajpheart.1993.264.5.h1734
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Also Consider

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  1. 1Capillary hydraulic conductivity is elevated by cGMP-dependent vasodilators.1992 · 85 citations
  2. 2Flow modulates coronary venular permeability by a nitric oxide-related mechanism1992 · 142 citations
  3. 3Effect of histamine on coronary microvascular permeability1984 · 12 citations
  4. 4Myogenic activity in isolated subepicardial and subendocardial coronary arterioles1988 · 218 citations
  5. 5Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein1989 · 83 citations