Key result
Fibroblast-enriched ferroptosis signature distinguishes DCM and links ferroptotic stress to progressive pro-fibrotic remodeling.
Population
Human heart failure (DCM) and controls
Comparison
DCM vs controls
Design
Single-cell analysis proof-of-concept study
Answers are grounded in this paper and cite their sources.
Ferroptosis signature in DCM fibroblasts warrants investigation as antifibrotic target; leaves open clinical translation.
Single-cell analysis of human heart failure identifies a fibroblast-enriched ferroptosis signature that distinguishes DCM from controls and reveals a pseudotime trajectory linking ferroptotic stress to progressive fibroblast activation and pro-fibrotic remodelling.
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Karampinos et al. (2026) studied this question. A fibroblast-enriched ferroptosis signature distinguishes dilated cardiomyopathy from controls and links ferroptotic stress to progressive pro-fibrotic remodelling in human heart failure.
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