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This research investigates the role of placental steroidogenic genes in producing androgens and estrogens during pregnancy.

The Expression of Placental 17β-Hydroxysteroid Dehydrogenase Genes Is Associated with the Elevation of Active Androgens and Estrogens in Pregnant Women, but Does Not Affect 11-Oxygenated C19 Steroids

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This research investigates the role of placental steroidogenic genes in producing androgens and estrogens during pregnancy.
Comprehensive analysis of steroidogenic gene expression in early and term placenta.
Assessment of plasma steroid levels in pregnant and non-pregnant women.
17β-hsd genes, including HSD17B1 and AKR1C3, were significantly upregulated in the term placenta.
Elevated plasma ratios of active sex steroids were found in pregnant women compared to non-pregnant women, indicating higher hormones but no change in 11-oxygenated androgens.

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Randomized trial analyzes steroidogenic gene expression and hormonal levels in pregnant women, highlighting insights into hormone production.

Yokohama et al. (2026) studied this question.

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Randomized trial analyzes steroidogenic gene expression and hormonal levels in pregnant women, highlighting insights into hormone production.