What question did this study set out to answer?

To determine whether placental 11β-hydroxysteroid dehydrogenase acts as an effective functional barrier against maternal glucocorticoids in intact human placental tissue.

February 1, 1997Clinical Endocrinology

Placental 11β‐hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure

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Authors

RBRafn BenediktssonReykjavík University ACAndrew A. CalderUniversidad Mayor de San Andrés CEChristopher R.W. EdwardsMaimonides Medical Center

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Implication

Ex vivo perfusion study demonstrates that placental 11β-HSD converts maternal cortisol to cortisone, indicating its role in guarding the fetus.

Key Points

To determine whether placental 11β-hydroxysteroid dehydrogenase acts as an effective functional barrier against maternal glucocorticoids in intact human placental tissue.
Perfused freshly isolated, intact human placentas obtained from randomly selected normal term deliveries using a dual-circuit perfusion system.
Introduced physiological concentrations of cortisol into the maternal circulation and quantified steroid metabolites in fetal effluent using silica columns and high-performance liquid chromatography.
Maternally administered cortisol was predominantly metabolized into cortisone, which was the only detected metabolic product, with no observed reverse conversion of cortisone to cortisol.
Pharmacological inhibition of 11β-hydroxysteroid dehydrogenase with glycyrrhetinic acid allowed maternal cortisol direct access across the placenta into the fetal circulation.

Cite This Study

Benediktsson et al. (1997) studied this question.

synapsesocial.com/papers/6a705152febe604dd70919f4 https://doi.org/10.1046/j.1365-2265.1997.1230939.x

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Implication

Ex vivo perfusion study demonstrates that placental 11β-HSD converts maternal cortisol to cortisone, indicating its role in guarding the fetus.

Placental 11β‐hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure

Discussion

Member takes

Implication

Key Points

Cite This Study

Placental 11β‐hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure

Discussion

Member takes

Implication

Key Points

Cite This Study

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