Synthesis of Spirooxindoles by Catalytic Tandem Reaction of 2-Arylidene-1,3-indanediones with 2-(2-Oxoindolin-3-yl)malononitriles

Pengxin Guo; Da‐Ming Du

doi:10.1039/d6ob00433d

January 1, 2026Organic & Biomolecular Chemistry

Synthesis of Spirooxindoles by Catalytic Tandem Reaction of 2-Arylidene-1,3-indanediones with 2-(2-Oxoindolin-3-yl)malononitriles

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Key Points

The aim is to develop a simple synthetic method for spirooxindoles using a tandem reaction.
Utilized catalytic tandem reaction involving 2-arylidene-1,3-indanediones and 2-(2-oxoindolin-3-yl)malononitriles.
Applied K2CO3 as a catalyst to facilitate the reaction.
Conducted cyclization reaction triggered by Michael addition.
Successfully synthesized spirooxindoles featuring benzofuran-1(3H)-one.
Achieved desired products through a one-pot reaction setup.
Demonstrated high efficiency and simplicity in the synthesis process.

Implication

Demonstrates an efficient method for synthesizing spirooxindoles, suggesting better synthetic pathways.

Abstract

A facile synthetic method has been developed for the synthesis of spirooxindoles bearing benzofuran-1(3H)-one. The Michael addition-triggered tandem cyclization reaction between 2-arylene-1,3-indanediones with 2-(2-oxoindolin-3-yl)malononitriles catalyzed by K2CO3 affording the spirooxindole...

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Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a056795a550a87e60a1f9fc https://doi.org/10.1039/d6ob00433d

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Synthesis of Spirooxindoles by Catalytic Tandem Reaction of 2-Arylidene-1,3-indanediones with 2-(2-Oxoindolin-3-yl)malononitriles

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of Spirooxindoles by Catalytic Tandem Reaction of 2-Arylidene-1,3-indanediones with 2-(2-Oxoindolin-3-yl)malononitriles

Key Points

Implication

Abstract

Discussion

Cite This Study

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