What does this research mean for the field?

Non-invasive thoracocardiography-derived peak aortic acceleration serves as a robust surrogate for invasive dP/dtmax to measure left ventricular contractility in rats. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether flow-derived indices obtained through non-invasive thoracocardiography can accurately surrogate the maximal rate of left ventricular pressure rise (dP/dtmax) without surgical access.

May 14, 2026Scientific ReportsOpen Access

Non-invasive left ventricular contractility indices derived from thoracocardiography in rats

Q: What is the clinical evidence from this study?

Study design: Other. Population: Healthy (preclinical animal model) (n=9). Intervention: Thoracocardiography (TCG) flow-derived indices vs. Invasive dP/dtmax (Millar catheter). Primary outcome: Correlation between TCG-derived peak aortic acceleration (Ap) and invasive dP/dtmax (r = 0.83, p=<0.001).

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Key result

Non-invasive thoracocardiography-derived peak aortic acceleration strongly correlates with invasive dP/dtmax in rats.

r = 0.83
P<0.001
n=9

Why the study?

Preclinical studies of cardiac contractility in rodents are limited by the invasiveness of current measurement techniques, prompting investigation into whether non-invasive thoracocardiography can serve as a surrogate for dP/dtmax.

Can non-invasive thoracocardiography (TCG) indices serve as robust surrogates for invasive left ventricular contractility (dP/dtmax) in rats?

Population

Anesthetized rats

Comparison

Thoracocardiography-derived indices vs invasive dP/dtmax reference during pharmacological hemodynamic challenge

Design

Preclinical validation study

Authors

LFLeandro Fontana-PiresInstitut polytechnique de Grenoble STStéphane TanguyInstitut polytechnique de Grenoble ACAgathe CambierAssociation pour l'Utilisation du Rein Artificiel dans la région Lyonnaise

Discussion

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Implication

May support non-invasive LV contractility monitoring via TCG in rat models; leaves open human validation.

Key Points

To determine whether flow-derived indices obtained through non-invasive thoracocardiography can accurately surrogate the maximal rate of left ventricular pressure rise (dP/dtmax) without surgical access.
Instrumented anesthetized rats (N=9) simultaneously with a non-invasive thoracocardiography sensor and an invasive reference Millar left intraventricular pressure probe.
Administered pharmacological challenges consisting of graded dobutamine infusions (2.8, 4.2, and 5.6 µg/kg/h) followed by DL-propranolol injection (0.89 mg/kg).
Calculated four thoracocardiography indices of early-systolic dynamics (peak velocity, peak acceleration, mean acceleration, and velocity ratio) and compared them to dP/dtmax using correlation and Bland–Altman analyses.
Peak aortic acceleration (Ap) displayed the strongest linear correlation with dP/dtmax (r = 0.83, p < 0.001), with all indices correlating significantly across pharmacological phases (r = 0.73 to 0.83, p < 0.01).
Dobutamine induced increases of 6% to 28% across Vp, Ap, Am, and dP/dtmax alongside a 73% increase in the velocity ratio, whereas DL-propranolol induced reductions of 28% to 47% below baseline across all indices.
Bland–Altman analyses revealed near-zero mean differences across all indices, demonstrating unbiased tracking of relative contractility changes under both positive and negative inotropic states.

Structured PICO

Can non-invasive thoracocardiography (TCG) indices serve as robust surrogates for invasive left ventricular contractility (dP/dtmax) in rats?

Population

Anesthetized rats

Intervention

Non-invasive thoracocardiography (TCG) to derive flow-based variables (peak aortic velocity, peak aortic acceleration, mean aortic acceleration, and the ratio of Vp^2 to time-to-peak velocity)

Comparator

Invasive left intraventricular pressure probe measuring dP/dtmax

Outcome

Correlation of TCG-based indices with dP/dtmax during pharmacological hemodynamic challengesurrogate

Main Result

Effect estimate: r = 0.83

p-value: p=<0.001

Thoracocardiography-derived peak aortic acceleration provides a robust, non-invasive surrogate for left ventricular contractility (dP/dtmax) in rats.

Limitations

General anesthesia was required for the experimental setup.
ECG modality was not synchronized with the left intraventricular pressure measurement.
Small sample size of 9 rats.

Cite This Study

Fontana-Pires et al. (2026) studied Healthy (preclinical animal model) (n=9). Thoracocardiography (TCG) flow-derived indices vs. Invasive dP/dtmax (Millar catheter) was evaluated on Correlation between TCG-derived peak aortic acceleration (Ap) and invasive dP/dtmax (r = 0.83, p=<0.001). Non-invasive thoracocardiography-derived peak aortic acceleration strongly correlated with invasive dP/dtmax (r = 0.83, p < 0.001) during pharmacological hemodynamic challenges in rats.

synapsesocial.com/papers/6a0567bca550a87e60a1fde6 https://doi.org/10.1038/s41598-026-52302-3

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Non-invasive left ventricular contractility indices derived from thoracocardiography in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

Non-invasive left ventricular contractility indices derived from thoracocardiography in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider