January 12, 2021Scientific ReportsOpen Access

Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse

View Full Paper

Ask AI

Bookmark

Why the study?

Invasive measurement of LV contractility (+dP/dt max) in mice is limited to a single terminal study, necessitating a noninvasive surrogate to enable repeated serial measurements in the same animals.

Population

Mice

Comparison

Baseline vs after dobutamine administration

Design

Simultaneous invasive catheter and noninvasive pulsed Doppler study

Authors

JPJorge Enrique Tovar PerezTexas A&M Health Science Center JOJesús Ortiz-UrbinaBrigham and Women's Hospital CHCelia Pena Heredia

Discussion

Member takes

Implication

May enable serial LV contractility assessment in mice; leaves open clinical validation.

Structured PICO

Population

16 wild-type C57BL/6J mice (Group 1: n=10, avg age 5 months, 4 males/6 females; Group 2: n=6, avg age 9 months, 3 males/3 females)

Intervention

Noninvasive measurement of aortic flow velocity parameters (peak aortic velocity, peak velocity squared/rise time, peak aortic acceleration, mean aortic acceleration) using a pulsed Doppler probe at baseline and after dobutamine administration

Comparator

Invasive measurement of left ventricular pressure (+dP/dt max or P') using an intravascular pressure catheter

Outcome

Correlation between noninvasive aortic flow velocity parameters and invasively measured left ventricular contractility (+dP/dt max)surrogate

Noninvasive Doppler-derived mean and peak aortic acceleration can serve as reliable surrogates for invasively measured left ventricular contractility in mice, enabling longitudinal studies without terminal invasive procedures.

Limitations

Did not measure pulse wave velocity
Echocardiography significantly underestimated parameters without angle correction

Cite This Study

Perez et al. (2021) studied this question.

synapsesocial.com/papers/6a70d6b522b3175134db589b https://doi.org/10.1038/s41598-020-79866-y

View Full Paper

Ask AI

Bookmark

Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider