December 1, 2002AJP Heart and Circulatory Physiology
Effects of changes in left ventricular contractility on indexes of contractility in mice
Population
Closed-chest mice
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May refine murine LV contractility assessment; leaves open translation to clinical echocardiography.
Structured PICO
P
Population
Closed-chest mice
I
Intervention
Three interventions altering contractility: 1) atrial pacing, 2) dobutamine infusion, 3) esmolol infusion
O
Outcome
Changes in load-independent parameters derived from pressure-volume (P-V) relations (ESPVR, dP/dt-EDV) and standard echocardiographic parameters (fractional shortening)surrogate
Contractile parameters derived from pressure-volume relations are superior to standard echocardiographic fractional shortening for detecting small changes in left ventricular contractility in murine models.
Cite This Study
Nemoto et al. (2002) studied this question.