Key result
Increased inotropy with dobutamine and digoxin significantly reduced the index of myocardial performance in dogs with chronic left ventricular dysfunction.
Why the study?
Does increased contractility with dobutamine or digoxin improve the index of myocardial performance in a canine model of left ventricular dysfunction?
Does increased contractility with dobutamine or digoxin improve the index of myocardial performance in a canine model of left ventricular dysfunction?
Absolute Event Rate: 0.33% vs 0.58%
p-value: p=<0.001
Increased inotropy with dobutamine or digoxin reduces the index of myocardial performance in a canine model of left ventricular dysfunction, primarily by shortening isovolumic contraction time.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for inotropes in canine LV dysfunction; leaves open translation to human heart failure management.
Steven J. Lavine (2006) studied Chronic left ventricular dysfunction (n=18). Dobutamine and Digoxin vs. Baseline chronic LV dysfunction was evaluated on Index of myocardial performance (IMP) (p=<0.001). Increased inotropy with dobutamine and digoxin significantly reduced the index of myocardial performance in dogs with chronic left ventricular dysfunction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: