Key result
Dopamine increases all LV contractility indices, with ERFS showing the greatest quantitative change.
Why the study?
The effects of acute changes in preload, afterload, and inotropic state on various indices of left ventricular contractility, including the exponential rate of fiber shortening, were not fully characterized in intact hearts.
How do acute changes in load and inotropic state affect the exponential rate of fiber shortening and other indices of myocardial contractility in anesthetized intact dogs?
Population
20 anesthetized intact dogs
Comparison
Baseline state vs acute preload, afterload, and inotropic interventions
Design
Experimental study in anesthetized intact dogs
Follow-up
Acute
Authors
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ERFS may outperform other indices in intact canine models; leaves open translation to human contractility assessment.
How do acute changes in load and inotropic state affect the exponential rate of fiber shortening and other indices of myocardial contractility in anesthetized intact dogs?
The exponential rate of fiber shortening (ERFS) is highly sensitive to positive inotropic interventions in an intact dog model, showing greater quantitative changes than other classical indices.
Lezo et al. (1987) studied None (animal model) (n=20). Acute changes in preload, afterload, and inotropic state vs. Baseline was evaluated on Left ventricular contractility indices including exponential rate of fiber shortening (ERFS). Acute changes in preload, afterload, and inotropic state altered contractility indices, with dopamine increasing all indices and ERFS showing the greatest quantitative change.
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